Fluid retention mediated by renal PPARgamma

Cell Metab. 2005 Aug;2(2):77-8. doi: 10.1016/j.cmet.2005.08.001.


Thiazolidinediones are activators of the nuclear receptor PPARgamma with proven efficacy on glucose homeostasis. However, treatment with these drugs often results in fluid retention and edema. Recent studies establish a role for PPARgamma in renal sodium reabsorption, providing a mechanism for the plasma volume expansion induced by these drugs.

MeSH terms

  • Animals
  • Body Fluids / metabolism
  • Edema / metabolism*
  • Humans
  • Kidney / drug effects
  • Kidney / metabolism*
  • PPAR gamma / metabolism*
  • Thiazolidinediones / pharmacology
  • Water-Electrolyte Imbalance


  • PPAR gamma
  • Thiazolidinediones