Expression of agouti-related peptide, neuropeptide Y, pro-opiomelanocortin and the leptin receptor isoforms in fetal mouse brain from pregnant dams on a protein-restricted diet

Paul L Terroni; Fred W Anthony; Mark A Hanson; Felino R A Cagampang

doi:10.1016/j.molbrainres.2005.07.002

Expression of agouti-related peptide, neuropeptide Y, pro-opiomelanocortin and the leptin receptor isoforms in fetal mouse brain from pregnant dams on a protein-restricted diet

Brain Res Mol Brain Res. 2005 Oct 31;140(1-2):111-5. doi: 10.1016/j.molbrainres.2005.07.002. Epub 2005 Aug 15.

Authors

Paul L Terroni¹, Fred W Anthony, Mark A Hanson, Felino R A Cagampang

Affiliation

¹ Centre for Developmental Origins of Health and Disease, University of Southampton, School of Medicine, Princess Anne Hospital, Level F mailpoint 887, Coxford Road, Southampton, UK.

PMID: 16099070
DOI: 10.1016/j.molbrainres.2005.07.002

Abstract

Expression of agouti-related peptide, neuropeptide Y, pro-opiomelanocortin and leptin receptor isoforms were found in fetal mouse brain at embryonic day 12 (E12). Levels of expression for these genes were altered in brains of E12 fetuses from pregnant dams on a protein-restricted diet, suggesting that the fetal brain is responsive to changes in maternal nutrition prior to birth.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Agouti-Related Protein
Animals
Brain / embryology*
Diet, Protein-Restricted*
Female
Fetus
Gene Expression Regulation, Developmental / physiology*
Intercellular Signaling Peptides and Proteins
Mice
Neuropeptide Y / genetics*
Pregnancy
Prenatal Exposure Delayed Effects*
Pro-Opiomelanocortin / genetics*
Proteins / genetics*
Receptors, Cell Surface / genetics*
Receptors, Leptin

Substances

Agouti-Related Protein
Intercellular Signaling Peptides and Proteins
Neuropeptide Y
Proteins
Receptors, Cell Surface
Receptors, Leptin
leptin receptor, mouse
Pro-Opiomelanocortin