MyoD and the transcriptional control of myogenesis

Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):585-95. doi: 10.1016/j.semcdb.2005.07.006.


The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development. Together with the Mef2 proteins and E proteins, these transcription factors are responsible for coordinating muscle-specific gene expression in the developing embryo. This review highlights recent studies regarding the molecular mechanisms by which the muscle-specific myogenic bHLH proteins interact with other regulatory factors to coordinate gene expression in a controlled and ordered manner.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / physiology*
  • Humans
  • Muscle Development / genetics
  • Muscle Development / physiology*
  • MyoD Protein / metabolism
  • MyoD Protein / physiology*
  • Transcription, Genetic / physiology*


  • MyoD Protein