Lysophospholipids in the nervous system

Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):46-51. doi: 10.1016/j.prostaglandins.2004.09.009.


This piece offers perspectives on the emerging roles of lysophospholipids, which include lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), for the biology and pathophysiology of the nervous system. It reflects opinions generated during a meeting sponsored by the National Institute on Drug Abuse (NIDA) entitled "Targeted Lipidomics: Signaling Lipids and Drugs of Abuse" held in Washington, D.C., 15-17 April 2004, organized by Dr. Rao Rapaka. Lysophospholipids represent one class of lipids that has many important actions mediated by G protein-coupled receptors. While influencing a large number of biologically important systems, this discussion will focus on the nervous system, including areas of future research.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Kinetics
  • Lipids / chemistry
  • Lysophospholipids / chemistry
  • Lysophospholipids / metabolism
  • Lysophospholipids / physiology*
  • Nervous System / metabolism*
  • Signal Transduction
  • Sphingosine / analogs & derivatives*
  • Sphingosine / metabolism


  • Lipids
  • Lysophospholipids
  • sphingosine 1-phosphate
  • Sphingosine
  • lysophosphatidic acid