Malaria parasites in mosquitoes: laboratory models, evolutionary temptation and the real world

Trends Parasitol. 2005 Oct;21(10):445-7. doi: 10.1016/


A recent study describing the effect of Plasmodium berghei infection on some Anopheles gambiae immune genes demonstrates that P. berghei is responsible for the upregulation of several genes involved in the immune response that affect parasitic development differently during the ookinete-to-oocyst developmental transition. It is important to question the relevance of such results, which are based on a laboratory model system, when discussing host-parasite interactions and, especially, the development of novel control strategies for malaria.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anopheles / genetics
  • Anopheles / immunology
  • Anopheles / parasitology*
  • Disease Models, Animal
  • Evolution, Molecular
  • Gene Expression Regulation
  • Host-Parasite Interactions
  • Humans
  • Insect Vectors / genetics
  • Insect Vectors / immunology
  • Insect Vectors / parasitology*
  • Malaria / transmission
  • Plasmodium berghei / growth & development*
  • Rats