Retinoids as therapeutic agents: today and tomorrow

Mini Rev Med Chem. 2005 Aug;5(8):755-60. doi: 10.2174/1389557054553820.

Abstract

Retinoids have shown beneficial therapeutic effects in pre-clinical and animal models for multiple pathologic indications, however severe adverse effects, restricting dosage and efficacy of oral formulations limit their use in patients. The focus of this review includes the actual medicinal use of retinoids and chemical efforts to generate highly selective and less toxic synthetic retinoids.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemistry, Pharmaceutical
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Dosage Forms
  • Drug Interactions
  • Humans
  • Models, Animal
  • Neoplasms / drug therapy*
  • Retinoids / adverse effects
  • Retinoids / chemistry
  • Retinoids / therapeutic use*
  • Skin Diseases / drug therapy*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Dosage Forms
  • Retinoids
  • Transcription Factors