A novel HLA allele, DRB1*1609, identified in the Chinese Han population*

Tissue Antigens. 2005 Sep;66(3):248-50. doi: 10.1111/j.1399-0039.2005.00443.x.

Abstract

A novel human leucocyte antigen-DRB1*16 (HLA-DRB1*16) allele (DRB1*1609) has been identified by sequencing-based typing (SBT) in Chinese Han population. This new allele has identical nucleotide sequence to DRB1*160101 in exon 2, except for a single-nucleotide substitution from A to T at position 127. This change leads to an amino acid change from tyrosine to phenylalanin at residue 47 (Y47F). SBT was performed for cloned DRB1*16-specific polymerase chain reaction fragment. The serological phenotype of DRB1*1609 is equivalent to DR16 antigen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Base Sequence
  • China
  • Exons
  • Family Health
  • Female
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Histocompatibility Testing
  • Humans
  • Male
  • Molecular Sequence Data
  • Pedigree
  • Phenotype
  • Phenylalanine / chemistry
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Tyrosine / chemistry

Substances

  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • HLA-DRB1*16:09 antigen
  • Tyrosine
  • Phenylalanine

Associated data

  • GENBANK/AY912074