Lupus anticoagulants and the risk of a first episode of deep venous thrombosis

J Thromb Haemost. 2005 Sep;3(9):1993-7. doi: 10.1111/j.1538-7836.2005.01485.x.


We have determined lupus anticoagulants, anti-beta2 glycoprotein I (beta2GPI) and antiprothrombin antibodies in the Leiden Thrombophilia Study, a population-based case-control study designed to determine risk factors for deep venous thrombosis (DVT). Lupus anticoagulant (LAC) was measured in 473 patients and 472 control subjects. Four control subjects (0.9%) and 14 patients (3.1%) had a positive LAC, resulting in a 3.6-fold increased risk [odds ratio (OR) 3.6, 95% CI: 1.2-10.9]. Of the total population, 49 were positive for anti-beta2GPI antibodies: 15 controls (3.4%) and 34 patients (7.5%), implying a 2.4-fold increased risk (95% CI: 1.3-4.2). Antiprothrombin antibodies were present in 114 subjects: 48 controls (11.0%) and 66 cases (14.6%) with an OR of 1.4 (95% CI: 1.0-2.1). When LAC was considered in the co-presence of antiprothrombin or anti-beta2GPI antibodies the OR increased to 10.1 (95% CI: 1.3-79.8). A LAC without a positive anti-beta2GPI or antiprothrombin test was not associated with a risk for DVT (OR 1.3, 95% CI: 0.3-6.0). This study demonstrates that the presence of LAC, anti-beta2GPI antibodies and antiprothrombin antibodies are risk factors for DVT in a general population. The strongest association holds for the combination LAC and the presence of anti-beta2GPI or antiprothrombin antibodies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Autoantibodies / blood
  • Case-Control Studies
  • Female
  • Glycoproteins / immunology
  • Humans
  • Lupus Coagulation Inhibitor / adverse effects*
  • Male
  • Middle Aged
  • Odds Ratio
  • Prothrombin / immunology
  • Risk Factors
  • Venous Thrombosis / epidemiology
  • Venous Thrombosis / etiology*
  • beta 2-Glycoprotein I


  • Autoantibodies
  • Glycoproteins
  • Lupus Coagulation Inhibitor
  • beta 2-Glycoprotein I
  • Prothrombin