The biology of Helicobacter pylori infection, a major risk factor for gastric adenocarcinoma

Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1853-8. doi: 10.1158/1055-9965.EPI-04-0784.


Helicobacter pylori infection of the human stomach is the most important risk factor for development of gastric cancer. Whereas persistent viral infection leads to a number of cancers, H. pylori was the first bacteria linked to a human cancer. The exact mechanisms that lead to cancer induction are not clear, but study of the bacterial factors important for colonization and the host responses to the infection are starting to yield important clues.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenocarcinoma* / immunology
  • Adenocarcinoma* / microbiology
  • Adolescent
  • Female
  • Gastric Mucosa / microbiology
  • Helicobacter Infections / complications*
  • Helicobacter Infections / immunology
  • Helicobacter pylori / immunology
  • Helicobacter pylori / pathogenicity*
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Stomach Neoplasms* / immunology
  • Stomach Neoplasms* / microbiology