Peroxisomal matrix protein import: the transient pore model

Nat Rev Mol Cell Biol. 2005 Sep;6(9):738-42. doi: 10.1038/nrm1710.

Abstract

Peroxisomes import folded, even oligomeric, proteins, which distinguishes the peroxisomal translocation machinery from the well-characterized translocons of other organelles. How proteins are transported across the peroxisomal membrane is unclear. Here, we propose a mechanistic model that conceptually divides the import process into three consecutive steps: the formation of a translocation pore by the import receptor, the ubiquitylation of the import receptors, and pore disassembly/ receptor recycling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Intracellular Membranes / metabolism*
  • Intracellular Membranes / ultrastructure
  • Membrane Transport Proteins / metabolism
  • Peroxisomal Targeting Signal 2 Receptor
  • Peroxisome-Targeting Signal 1 Receptor
  • Peroxisomes / metabolism*
  • Peroxisomes / ultrastructure
  • Protein Sorting Signals
  • Protein Transport / physiology*
  • Receptors, Cytoplasmic and Nuclear / metabolism

Substances

  • Membrane Transport Proteins
  • Peroxisomal Targeting Signal 2 Receptor
  • Peroxisome-Targeting Signal 1 Receptor
  • Protein Sorting Signals
  • Receptors, Cytoplasmic and Nuclear