Adaptive immune responses in acute and chronic hepatitis C virus infection

Nature. 2005 Aug 18;436(7053):946-52. doi: 10.1038/nature04079.


The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally. Recent studies have yielded important insights into immunity to HCV, in particular revealing the central role of T cells in viral control and clearance. Other key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Hepacivirus / genetics
  • Hepacivirus / immunology*
  • Hepacivirus / pathogenicity
  • Hepatitis C / immunology*
  • Hepatitis C / pathology
  • Hepatitis C / virology
  • Hepatitis C, Chronic / immunology*
  • Hepatitis C, Chronic / pathology
  • Hepatitis C, Chronic / virology
  • Humans
  • Liver / pathology
  • Liver / virology
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology