A case-control study to examine HLA haplotype associations in patients with posttreatment chronic Lyme disease

J Infect Dis. 2005 Sep 15;192(6):1010-3. doi: 10.1086/432733. Epub 2005 Aug 4.


In a comparison of 95 patients with systemic symptoms that persisted after antibiotic treatment for acute Lyme disease (posttreatment chronic Lyme disease) and 104 control subjects without such symptoms after antibiotic treatment, we sought associations between human leukocyte antigen class II (DRB1 and DQB1) markers and posttreatment chronic Lyme disease. No strong association between posttreatment chronic Lyme disease and any class II allele or genotype was found.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease
  • HLA-DQ Antigens / genetics
  • HLA-DQ beta-Chains
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Haplotypes*
  • Humans
  • Lyme Disease / complications*
  • Lyme Disease / drug therapy
  • Lyme Disease / genetics*
  • Male
  • Middle Aged


  • HLA-DQ Antigens
  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen
  • HLA-DR Antigens
  • HLA-DRB1 Chains