Chemokine control of lymphocyte trafficking: a general overview

Immunology. 2005 Sep;116(1):1-12. doi: 10.1111/j.1365-2567.2005.02183.x.


Chemokines are a large family of small, generally secreted polypeptides which guide lymphocyte movement throughout the body by controlling integrin avidity and inducing migration. Here, we look at recent, exciting findings on chemokine function throughout lymphocyte development and co-ordinated T and B cell migration during immune responses. Finally, we will review data on the regional control of immunity by tissue-specific chemokine receptors on effector/memory lymphocytes.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibody Formation / immunology
  • B-Lymphocytes / immunology
  • Chemokines / immunology*
  • Chemotaxis, Leukocyte / immunology*
  • Humans
  • Lymphocyte Cooperation / immunology
  • Lymphocytes / immunology*
  • T-Lymphocytes / immunology


  • Chemokines