IGF-1, inflammation and stem cells: interactions during muscle regeneration

Trends Immunol. 2005 Oct;26(10):535-42. doi: 10.1016/j.it.2005.08.002.


Insulin-like growth factor-I (IGF-1) is an important mediator in numerous developmental processes, such as proliferation, differentiation, survival, growth, apoptosis and regeneration. Mouse genetics have provided important insights into the signalling mechanisms that are necessary for the coordination of muscle repair. Recent studies on the role of IGF-1 in the promotion of cell recruitment to the injured muscle and the subsequent resolution of the inflammatory response have unveiled new perspectives into local repair mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Inflammation / immunology
  • Insulin-Like Growth Factor I / immunology*
  • Mice
  • Models, Immunological
  • Muscle, Skeletal / immunology
  • Muscle, Skeletal / physiology*
  • Regeneration / immunology*
  • Signal Transduction / immunology
  • Stem Cells / immunology


  • Insulin-Like Growth Factor I