G-protein beta3 Subunit C825T Polymorphism Tends to Be Associated With Seasonal Variation in Young Male College Students

Neuropsychobiology. 2005;52(3):135-9. doi: 10.1159/000087559. Epub 2005 Aug 17.


This study investigated the relationship between G-protein beta(3) subunit (GNB3) C825T polymorphism and seasonal variation in 189 young male college students. The subjects were genotyped for C825T and were evaluated by the Seasonality Pattern Assessment Questionnaire. The Global Seasonality Score (GSS) between the three genotypes revealed a marginal difference. The heterozygotes showed significantly higher seasonal variations in GSS than the homozygotes. The prevalence of heterozygotes tended to be higher in seasonals compared with normal subjects, although it was not statistically significant. These results suggest that GNB3 C825T polymorphism tends to be related to seasonal variation in mood and behavior in the normal population.

MeSH terms

  • Adult
  • Affect / physiology
  • Behavior / physiology
  • DNA / genetics
  • Gene Frequency
  • Genotype
  • Heterotrimeric GTP-Binding Proteins / genetics*
  • Humans
  • Korea / epidemiology
  • Male
  • Polymorphism, Genetic / genetics*
  • Psychological Tests
  • Seasons*
  • Surveys and Questionnaires


  • G-protein beta3 subunit
  • DNA
  • Heterotrimeric GTP-Binding Proteins