The role of timing and intensity of rehabilitation therapies

Top Stroke Rehabil. 2005 Summer;12(3):46-57. doi: 10.1310/ETDP-6DR4-D617-VMVF.


In both animal and clinical studies, motor rehabilitation and training increase cortical representation and improve recovery, whereas lack of training decreases cortical representation for particular motor functions. In animals, delays in providing rehabilitation reduce the impact of therapy with a worsening in motor outcomes and a corresponding reduction in cortical reorganization. In clinical studies, there is an association between earlier admission to rehabilitation and better outcomes that correlates with animal work both in terms of functional gains from chronic stroke deficits and cortical reorganization. There is a likely relationship between therapy intensity and improvements in functional outcomes. Clinically, greater intensity of stroke rehabilitation has been associated with improved outcomes.

Publication types

  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Haplorhini
  • Humans
  • Motor Skills Disorders / etiology*
  • Motor Skills Disorders / rehabilitation*
  • Physical Therapy Modalities
  • Prognosis
  • Stroke Rehabilitation*
  • Time Factors
  • Treatment Outcome