Injury reactive myelin/oligodendrocyte-derived axon growth inhibition in the adult mammalian central nervous system

Brain Res Brain Res Rev. 2005 Sep;49(2):295-9. doi: 10.1016/j.brainresrev.2004.10.007.


Myelin inhibition is considered a constitutive, static, repulsive barrier not reactive to a central nervous system (CNS) lesion. However, recent evidence underlines the existence of considerable add-on axon growth inhibition upon CNS injury. This postlesional, reactive myelin/oligodendrocyte-derived inhibition will require the development of novel screening approaches and therapeutic reagents to promote axonal regeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Central Nervous System Diseases / pathology*
  • Central Nervous System Diseases / physiopathology*
  • Gene Expression Regulation
  • Models, Neurological
  • Myelin Proteins / metabolism*
  • Myelin-Associated Glycoprotein
  • Nerve Regeneration
  • Oligodendroglia / metabolism*
  • Signal Transduction


  • Myelin Proteins
  • Myelin-Associated Glycoprotein