Proadrenomedullin N-terminal peptide and cortistatin activation of MrgX2 receptor is based on a common structural motif

Eur J Pharmacol. 2005 Sep 5;519(1-2):191-3. doi: 10.1016/j.ejphar.2005.07.001.

Abstract

The G protein-coupled receptor MrgX2 belongs to the large family of the Mas-related genes or sensory neuron-specific G protein-coupled receptors. The MrgX2 receptor has been shown to be activated by the peptides cortistatin and proadrenomedullin N-terminal peptides (PAMP). Here we investigated the structure activity relationship of PAMP and identified key structural features that are shared with cortistatin and might explain why two apparently unrelated peptides are able to activate a single G protein-coupled receptor.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenomedullin
  • Amino Acid Motifs / genetics
  • Amino Acid Sequence
  • Binding Sites / genetics
  • Binding, Competitive
  • Humans
  • Molecular Sequence Data
  • Nerve Tissue Proteins
  • Neuropeptides / chemistry
  • Neuropeptides / genetics
  • Neuropeptides / metabolism*
  • Protein Precursors / chemistry
  • Protein Precursors / genetics
  • Protein Precursors / metabolism*
  • Proteins / chemistry
  • Proteins / genetics
  • Proteins / metabolism*
  • Receptors, G-Protein-Coupled
  • Receptors, Neuropeptide / metabolism*

Substances

  • MRGPRX2 protein, human
  • Nerve Tissue Proteins
  • Neuropeptides
  • Protein Precursors
  • Proteins
  • Receptors, G-Protein-Coupled
  • Receptors, Neuropeptide
  • cortistatin
  • proadrenomedullin
  • Adrenomedullin