GnRH antagonist in the adjuvant treatment of a recurrent ovarian granulosa cell tumor: a case report

Gynecol Oncol. 2005 Dec;99(3):764-6. doi: 10.1016/j.ygyno.2005.07.007. Epub 2005 Aug 19.


Background: Ovarian granulosa cell tumors (GCT) are usually treated by surgery and chemotherapy. Successful response to GnRH agonists as an adjuvant therapy has previously been reported. In this case of recurrent GCT, we used a GnRH antagonist.

Case: A 78-year-old woman underwent surgery for an ovarian granulosa cell tumor (pT1a N0 Mx). Six months later, laparotomy revealed an inoperable recurrence of the tumor. Experimental treatment with a GnRH antagonist was not clearly successful. This is in contrast to the previously proven benefit of GnRH agonist therapy in this type of malignancy and to the positive response elicited by GnRH antagonists in epithelial ovarian tumors.

Conclusion: GnRH antagonist therapy had no demonstrable efficacy in the treatment of a poorly differentiated and aggressive recurrent granulosa cell tumor.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chemotherapy, Adjuvant
  • Female
  • Gonadotropin-Releasing Hormone / analogs & derivatives*
  • Gonadotropin-Releasing Hormone / antagonists & inhibitors*
  • Gonadotropin-Releasing Hormone / therapeutic use
  • Granulosa Cell Tumor / drug therapy*
  • Granulosa Cell Tumor / surgery
  • Humans
  • Neoplasm Recurrence, Local / drug therapy
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / surgery


  • Gonadotropin-Releasing Hormone
  • ganirelix