Is mammographic density, as currently measured, a robust surrogate marker for breast cancer?

Gynecol Endocrinol. 2005 Jul;21 Suppl 1:17-21. doi: 10.1080/09513590400030004.

Abstract

In order to determine current beliefs concerning the relevance of breast mammographic percent density (MPD) as a surrogate marker for breast cancer, the panel and the delegates completed a questionnaire. There was general agreement between the panel and delegates on most aspects, although the delegates were unsure whether high breast MPD is a contraindication for hormone therapy and tended to err on the side of caution in suggesting that estrogen and estrogen/progestogen therapy should be stopped before screening mammography. The overall consensus of the panel and the delegates was that breast MPD should become an important clinical tool, and that carefully designed studies are needed to determine exactly how it can be best used to guide clinical decision-making.

Publication types

  • Consensus Development Conference

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers
  • Breast / drug effects*
  • Breast / pathology
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / etiology
  • Contraindications
  • Estrogen Receptor Modulators / pharmacology
  • Estrogen Replacement Therapy / adverse effects*
  • Female
  • Humans
  • Mammography*
  • Middle Aged
  • Norpregnenes / pharmacology
  • Risk Factors
  • Surveys and Questionnaires

Substances

  • Biomarkers
  • Estrogen Receptor Modulators
  • Norpregnenes
  • tibolone