Current trends in the management of chronic myeloid leukaemia

Br J Hosp Med. 1992 Jun;47(11):816-23.


Conventional or alkylating treatment for chronic myeloid leukaemia has little impact on overall survival. Recent treatments, however, are encouraging. Alpha interferon may prolong the chronic phase in some patients, while allogeneic bone marrow transplantation is curative in over 50% of patients with HLA-compatible donors.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Bone Marrow Transplantation* / immunology
  • Graft vs Host Disease / prevention & control
  • HLA Antigens
  • Humans
  • Interferon-alpha / therapeutic use
  • Leukemia, Myeloid, Accelerated Phase / therapy
  • Leukemia, Myeloid, Chronic-Phase / mortality
  • Leukemia, Myeloid, Chronic-Phase / pathology
  • Leukemia, Myeloid, Chronic-Phase / therapy*
  • Transplantation, Homologous


  • Antineoplastic Agents
  • HLA Antigens
  • Interferon-alpha