Regulation of cyclooxygenase catalysis by hydroperoxides

Biochem Biophys Res Commun. 2005 Dec 9;338(1):25-33. doi: 10.1016/j.bbrc.2005.08.030. Epub 2005 Aug 15.

Abstract

Activation of cyclooxygenase catalysis in prostaglandin H synthase-1 and -2 by peroxide-dependent formation of a tyrosyl radical is emerging as an important part of regulating cellular production of bioactive prostanoids. This review discusses the mechanism of tyrosyl radical formation and the influence of peroxide, fatty acid, peroxidase cosubstrate, and protein structure on the activation process and cyclooxygenase catalysis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Hydrogen Peroxide / chemistry*
  • Hydrogen Peroxide / metabolism*
  • Prostaglandin-Endoperoxide Synthases / chemistry*
  • Prostaglandin-Endoperoxide Synthases / metabolism*

Substances

  • Hydrogen Peroxide
  • Prostaglandin-Endoperoxide Synthases