Urinary interleukin-8 is elevated in urinary tract infections independently of the causative germs

Cytokine. 2005 Sep 21;31(6):415-8. doi: 10.1016/j.cyto.2005.06.009.


Interleukin-8 elevation in urine during urinary tract infections (UTIs) has been documented for different uropathogenic germs in 85 patients. We showed that for 17 different isolates, IL-8 was increased in 92% of UTIs with an average value of 627 pg/ml for infected, as compared to 45 pg/ml for uninfected patients. We suggest that the high negative predictive value of the IL-8 urine assay could be useful to eliminate UTIs in routine screenings.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents
  • Bacterial Infections / diagnosis*
  • Bacterial Infections / microbiology
  • Bacterial Infections / urine
  • Humans
  • Interleukin-8 / urine*
  • Neutrophils
  • Predictive Value of Tests
  • Urinary Tract Infections / diagnosis*
  • Urinary Tract Infections / microbiology
  • Urinary Tract Infections / urine


  • Anti-Bacterial Agents
  • Interleukin-8