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Comparative Study
, 8 (9), 1139-41

Selective Inhibition of 2-AG Hydrolysis Enhances Endocannabinoid Signaling in Hippocampus

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Comparative Study

Selective Inhibition of 2-AG Hydrolysis Enhances Endocannabinoid Signaling in Hippocampus

Judit K Makara et al. Nat Neurosci.

Erratum in

  • Nat Neurosci. 2007 Jan;10(1):134

Abstract

The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that two previously unknown inhibitors of monoacylglycerol lipase, a presynaptic enzyme that hydrolyzes 2-AG, increase 2-AG levels and enhance retrograde signaling from pyramidal neurons to GABAergic terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and point to monoacylglycerol lipase as a possible drug target.

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