Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons

Nat Neurosci. 2005 Sep;8(9):1142-4. doi: 10.1038/nn1517. Epub 2005 Aug 7.

Abstract

Ablation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Death / drug effects
  • Disease Models, Animal
  • Electroencephalography / methods
  • Electromyography / methods
  • Immunohistochemistry / methods
  • Immunotoxins / toxicity*
  • Neurons / pathology*
  • Neurons / physiology
  • Polysomnography / methods
  • Rats
  • Receptors, Neurokinin-1 / metabolism
  • Respiratory Center / injuries
  • Respiratory Center / pathology*
  • Ribosome Inactivating Proteins, Type 1
  • Saporins
  • Sleep Apnea Syndromes / chemically induced
  • Sleep Apnea Syndromes / pathology*
  • Sleep Apnea Syndromes / physiopathology
  • Sleep, REM / drug effects
  • Sleep, REM / physiology
  • Substance P / analogs & derivatives*
  • Substance P / toxicity
  • Time Factors
  • Wakefulness / drug effects
  • Wakefulness / physiology

Substances

  • Immunotoxins
  • Receptors, Neurokinin-1
  • Ribosome Inactivating Proteins, Type 1
  • substance P-saporin
  • Substance P
  • Saporins