Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats

Coll Antropol. 2005 Jun;29(1):321-5.

Abstract

We evaluated the role of human gastric pentadecapeptide BPC 157 in corneal epithelial defects healing in rats. 48 rats, in 4 groups (N=12). Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e., at 0, 8, 16, 24, 32, 40 h). Lesions were photographed before application or sacrifice (at 48 h). Defect area was analyzed using a special program. Through 48 hour period a steady recovery is noted in controls. Recovery was markedly accelerated in eyes on microg- or ng-topical regimen of BPC 157 (p < 0.05). Of note, unlike control lesion present also after 48 h, these lesions disappeared already following 40 h (microg) or 48 h (ng) post-injury. BPC 157 was shown to be effective in promoting corneal defects healing in rats. Results were dose dependent.

MeSH terms

  • Animals
  • Anti-Ulcer Agents / pharmacology*
  • Corneal Diseases / drug therapy*
  • Corneal Diseases / veterinary
  • Epithelium
  • Male
  • Peptide Fragments / pharmacology*
  • Proteins / pharmacology*
  • Rats
  • Rats, Wistar

Substances

  • Anti-Ulcer Agents
  • Peptide Fragments
  • Proteins
  • BPC 157