To avoid the clinical manifestation of a vascular disease like stroke it is necessary to detect early vascular signs, to begin a therapy before the outbreak of the vascular disease happens. "TalkingEyes-and-more" is an interdisciplinary and quality-assessed program for prevention of vascular diseases. In several "screening-centers" in Germany interested citized were examined by non-invasive and fast methods to estimate the vascular risk. The examinations were performed on site, the medical evaluation of the data and images were performed centrally in the reading center of the Private Center of Preventive Medicine and Eye Diagnostics" in Erlangen by medical doctors. Alterations of the microvessels become often at first visible in retinal vessels. "TalkingEyes-and-more" examined telemedically the retinal vessels by a patented approach regarding microangiopathic abnormalities. In addition other risk factors like arterial blood pressure, intima media thickness of the carotid artery, cholesterol, fasting glucose, extended bodymass index, and others were documented. By these data a risk index is calculated and a proposal for improving the risk factors is generated.