The protective effects of Achillea L. species native in Turkey against H(2)O(2)-induced oxidative damage in human erythrocytes and leucocytes

J Ethnopharmacol. 2005 Nov 14;102(2):221-7. doi: 10.1016/j.jep.2005.06.018. Epub 2005 Aug 22.


The aim of the present study was to investigate the protective effects of infusions prepared from 15 Achillea (Asteraceae) species against H(2)O(2)-induced oxidative damage in human erythrocytes and leucocytes used in traditional Turkish medicine. CAT, SOD and GPx activities, effects of LPO and GSH levels of the infusions on erythrocytes and leucocytes were assessed. The results indicated that all infusions of Achillea species were effective on antioxidant enzyme systems of erythrocytes and leucocytes when compared with H(2)O(2) group. Achillea falcata was the most effective one on CAT, GPx and SOD enzyme systems of erythrocytes. Among plant infusions, Achillea crithmifolia and Achillea nobilis subsp. neilrechii showed the highest activities on CAT, while Achillea millefolium subsp. pannonica on SOD, Achillea teretifolia on GPx and Achillea nobilis subsp. sipylea on LPO enzyme systems of leucocytes. The present results demonstrate that infusions of Achillea species are a potential source of natural antioxidants for treatment and prevention of diseases in which LPO takes place.

MeSH terms

  • Achillea*
  • Antioxidants / pharmacology*
  • Erythrocytes / drug effects*
  • Erythrocytes / metabolism
  • Humans
  • Hydrogen Peroxide / toxicity
  • Leukocytes / drug effects*
  • Leukocytes / metabolism
  • Lipid Peroxidation / drug effects
  • Medicine, Traditional
  • Plant Extracts / pharmacology*
  • Turkey


  • Antioxidants
  • Plant Extracts
  • Hydrogen Peroxide