Combining Electron Microscopy and Comparative Protein Structure Modeling

Curr Opin Struct Biol. 2005 Oct;15(5):578-85. doi: 10.1016/


Recently, advances have been made in methods and applications that integrate electron microscopy density maps and comparative modeling to produce atomic structures of macromolecular assemblies. Electron microscopy can benefit from comparative modeling through the fitting of comparative models into electron microscopy density maps. Also, comparative modeling can benefit from electron microscopy through the use of intermediate-resolution density maps in fold recognition, template selection and sequence-structure alignment.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cryoelectron Microscopy*
  • Crystallography, X-Ray
  • Models, Molecular*
  • Protein Conformation*