Preterm premature rupture of membranes: perspectives surrounding controversies in management

Am J Perinatol. 2005 Aug;22(6):287-97. doi: 10.1055/s-2005-870659.


Preterm premature rupture of the membranes (PPROM) occurs in approximately 3% of all pregnancies, and accounts for one third of all preterm births. Despite its prevalence, optimal management of PPROM remains largely undefined and lacks conformity. In this article, we review the pathophysiology of PPROM, and summarize the available literature describing various management strategies in an effort to define current controversies in the management of PPROM.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Delivery, Obstetric / methods
  • Female
  • Fetal Membranes, Premature Rupture / physiopathology
  • Fetal Membranes, Premature Rupture / therapy*
  • Humans
  • Inflammation / etiology
  • Inflammation / physiopathology
  • Perinatology / methods*
  • Perinatology / trends*
  • Practice Guidelines as Topic
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy
  • Pregnancy Complications, Infectious / etiology
  • Pregnancy Complications, Infectious / physiopathology
  • Tocolysis / methods


  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents