Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23

Cytogenet Cell Genet. 1992;60(2):114-6. doi: 10.1159/000133316.


Oncogenic activation of the MCF.2 cell line-derived transforming sequence gene (MCF2) occurs through substitution of part of its 5' coding region by unrelated nonsyntenic sequences. Analysis of the MCF2 oncogene locus revealed complex recombination events involving four discontinuous human DNA segments. The upstream replacing sequence, named URS, represents the farthest 5' portion of the locus. The URS sequence maps to the D15S93 locus on human chromosome 15q15----q23.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosomes, Human, Pair 15*
  • Humans
  • Molecular Sequence Data
  • Oncogenes / genetics*
  • Recombination, Genetic / genetics
  • Restriction Mapping