Shortcut to fmoc-protected phosphinic pseudodipeptidic blocks

Org Lett. 2005 Sep 1;7(18):4049-52. doi: 10.1021/ol051622y.

Abstract

A three-component condensation reaction of Fmoc-carbamate, aldehydes, and alkylphosphinic acids provides a new, direct, and efficient method for synthesizing Fmoc-protected phosphinic pseudodipeptidic blocks, directly usable for solid-phase peptide synthesis. [reaction: see text]

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Combinatorial Chemistry Techniques*
  • Fluorenes / chemistry*
  • Molecular Structure
  • Peptides / chemical synthesis*
  • Phosphinic Acids / chemistry*

Substances

  • Fluorenes
  • Peptides
  • Phosphinic Acids