The pathophysiology of stroke in mitochondrial disorders

Mitochondrion. 2004 Sep;4(5-6):665-74. doi: 10.1016/j.mito.2004.07.019. Epub 2004 Nov 2.


Stroke occurs with an increased frequency in patients with mitochondrial disorders and is a characteristic feature of the MELAS phenotype. This article explores the proposed mechanisms by which mitochondrial dysfunction may contribute to both vascular and non-vascular strokes and stroke-like episodes. The clinical features, neuroimaging, and pathologic findings of MELAS are reviewed as evidence for a cytopathologic basis for stroke in mitochondrial disorders.