The role of blood-brain barrier permeability in brain tumor imaging and therapeutics

AJR Am J Roentgenol. 2005 Sep;185(3):763-7. doi: 10.2214/ajr.185.3.01850763.


Objective: Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes.

Conclusion: Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Blood-Brain Barrier / physiology*
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / physiopathology
  • Brain Neoplasms / therapy*
  • Contrast Media
  • Humans
  • Magnetic Resonance Imaging*
  • Neovascularization, Pathologic / diagnosis
  • Neovascularization, Pathologic / physiopathology
  • Neovascularization, Pathologic / therapy
  • Permeability


  • Contrast Media