Regulation of 5-lipoxygenase enzyme activity

Biochem Biophys Res Commun. 2005 Dec 9;338(1):102-10. doi: 10.1016/j.bbrc.2005.08.013. Epub 2005 Aug 11.


In this article, regulation of human 5-lipoxygenase enzyme activity is reviewed. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide. Also, studies on phosphorylation of 5-lipoxygenase and nuclear localization sequences are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arachidonate 5-Lipoxygenase / chemistry*
  • Arachidonate 5-Lipoxygenase / metabolism*
  • Humans


  • Arachidonate 5-Lipoxygenase