Sequence similarity between macrolide-resistance determinants and ATP-binding transport proteins

Gene. 1992 Jun 15;115(1-2):93-6. doi: 10.1016/0378-1119(92)90545-z.


The three macrolide-resistance-encoding genes, tlrC from Streptomyces fradiae, srmB from Streptomyces ambofaciens, and carA from Streptomyces thermotolerans, encode proteins that possess significant sequence similarity to ATP-dependent transport proteins. The N-terminal and C-terminal halves of these proteins are very similar to each other and contain highly conserved regions that resemble ATP-binding domains typically present within the superfamily of ATP-dependent transport proteins. These observations suggest that the mechanism by which these genes confer resistance to macrolides is due to export of the antibiotics, a process that is driven by energy derived from ATP hydrolysis.

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Adenosine Triphosphate / metabolism*
  • Amino Acid Sequence
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • Carrier Proteins / chemistry*
  • DNA-Binding Proteins / chemistry
  • Drug Resistance, Microbial / genetics
  • Macrolides
  • Molecular Sequence Data
  • Protein Binding
  • Sequence Alignment
  • Streptomyces / chemistry
  • Streptomyces / genetics*


  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carrier Proteins
  • DNA-Binding Proteins
  • Macrolides
  • Adenosine Triphosphate

Associated data

  • GENBANK/M57437
  • GENBANK/M74890
  • GENBANK/M74891
  • GENBANK/M74892
  • GENBANK/M79309
  • GENBANK/M79310
  • GENBANK/M80346
  • GENBANK/S38794
  • GENBANK/S38797
  • GENBANK/S38798
  • GENBANK/S38799