Abstract
The three macrolide-resistance-encoding genes, tlrC from Streptomyces fradiae, srmB from Streptomyces ambofaciens, and carA from Streptomyces thermotolerans, encode proteins that possess significant sequence similarity to ATP-dependent transport proteins. The N-terminal and C-terminal halves of these proteins are very similar to each other and contain highly conserved regions that resemble ATP-binding domains typically present within the superfamily of ATP-dependent transport proteins. These observations suggest that the mechanism by which these genes confer resistance to macrolides is due to export of the antibiotics, a process that is driven by energy derived from ATP hydrolysis.
MeSH terms
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Adenosine Triphosphate / chemistry
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Adenosine Triphosphate / metabolism*
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Amino Acid Sequence
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics*
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Carrier Proteins / chemistry*
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DNA-Binding Proteins / chemistry
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Drug Resistance, Microbial / genetics
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Macrolides
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Molecular Sequence Data
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Protein Binding
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Sequence Alignment
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Streptomyces / chemistry
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Streptomyces / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carrier Proteins
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DNA-Binding Proteins
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Macrolides
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Adenosine Triphosphate
Associated data
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GENBANK/M57437
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GENBANK/M74890
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GENBANK/M74891
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GENBANK/M74892
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GENBANK/M79309
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GENBANK/M79310
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GENBANK/M80346
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GENBANK/S38794
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GENBANK/S38797
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GENBANK/S38798
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GENBANK/S38799