Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans

J Nat Prod. 2005 Aug;68(8):1300-2. doi: 10.1021/np050141k.

Abstract

Dereplication of the antifungal extracts of Aspergillus flavus indicated that the primary antifungal compound present was the known aspirochlorine (1). Preparative isolation work resulted in the identification of the new compounds tetrathioaspirochlorine (2) and cyclo(D-N-methyl-Leu-L-Trp) (3).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Aspergillus flavus / chemistry*
  • Azoles / pharmacology*
  • Candida albicans / drug effects*
  • Drug Resistance, Fungal*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycotoxins / chemistry
  • Mycotoxins / classification
  • Mycotoxins / isolation & purification*
  • Mycotoxins / pharmacology
  • Spiro Compounds / chemistry
  • Spiro Compounds / classification
  • Spiro Compounds / isolation & purification*
  • Spiro Compounds / pharmacology

Substances

  • Antifungal Agents
  • Azoles
  • Mycotoxins
  • Spiro Compounds
  • aspirochlorine
  • tetrathioaspirochlorine