Role of 14-3-3 proteins in eukaryotic signaling and development

Curr Top Dev Biol. 2005;68:281-315. doi: 10.1016/S0070-2153(05)68010-6.

Abstract

14-3-3 genes encode a ubiquitous family of highly conserved eukaryotic proteins from fungi to humans and plants with several molecular and cellular functions. Most notably, 14-3-3 proteins bind to phosphoserine/phosphothreonine motifs in a sequence-specific manner. More than 100 14-3-3 binding partners involved in signal transduction, cell cycle regulation, apoptosis, stress responses, and malignant transformation have been identified. The 14-3-3 proteins form homodimers and heterodimers, and there is redundancy of the binding specificity and function of different 14-3-3 proteins because of their highly similar amino acid sequence and tertiary structure. 14-3-3 proteins can regulate target protein function by several mechanisms. Although the molecular and cellular functions of 14-3-3 proteins have been well studied, there have been fewer studies addressing the in vivo role of 14-3-3s. Here we review what is known about 14-3-3 proteins during eukaryotic development.

Publication types

  • Review

MeSH terms

  • 14-3-3 Proteins / chemistry
  • 14-3-3 Proteins / genetics
  • 14-3-3 Proteins / metabolism*
  • Animals
  • Cell Cycle
  • Drosophila / genetics
  • Drosophila / growth & development
  • Drosophila / metabolism
  • Eukaryotic Cells
  • Germination
  • Humans
  • MAP Kinase Signaling System
  • Mice
  • Neurons / cytology
  • Neurons / metabolism
  • Plant Development
  • Plants / genetics
  • Plants / metabolism
  • Signal Transduction
  • Xenopus / genetics
  • Xenopus / growth & development
  • Xenopus / metabolism
  • Yeasts / genetics
  • Yeasts / growth & development
  • Yeasts / metabolism

Substances

  • 14-3-3 Proteins