Lysosomal proteolysis in skeletal muscle

Int J Biochem Cell Biol. 2005 Oct;37(10):2098-114. doi: 10.1016/j.biocel.2005.02.029. Epub 2005 Mar 23.


Lysosomal proteases are abundantly expressed in fetal muscles, but poorly represented in the adult skeletal muscles. The lysosomal proteolytic system is nonetheless stimulated in adult muscles in a variety of pathological conditions. Furthermore, recent investigations describe autophagosomes in muscle fibers in vitro and in vivo, and report myopathies with excessive autophagy. This review presents our current knowledge about the lysosomal proteolytic system and summarizes the evidences pertaining to the role of lysosomes and autophagosomes in muscle physiology and pathology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autophagy
  • Cathepsins / genetics
  • Cathepsins / metabolism
  • Humans
  • Lysosomes / enzymology
  • Lysosomes / metabolism*
  • Membrane Proteins / metabolism
  • Muscle, Skeletal / metabolism*
  • Muscular Diseases / metabolism
  • Myofibrils / metabolism
  • Peptide Hydrolases / metabolism


  • Membrane Proteins
  • Cathepsins
  • Peptide Hydrolases