Transcriptional signaling from membrane raft-associated glucocorticoid receptor

Biochem Biophys Res Commun. 2005 Oct 14;336(1):3-8. doi: 10.1016/j.bbrc.2005.08.057.

Abstract

The contribution of plasma membrane-associated glucocorticoid receptor (GR) to transcriptional signaling is unclear. We observed GR in low-density detergent-resistant membrane (DRM) rafts derived from human hepatoma Hep3B cells in complexes with caveolin-1, HSP90, and STAT3. In transient transfection assays, GR-stimulated transcriptional signaling was reversibly inhibited by membrane-raft disrupters filipin III and progesterone. These data provide clear evidence for a functional contribution of DRM-associated GR to transcriptional signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Caveolin 1
  • Caveolins / metabolism
  • Cell Line, Tumor
  • Cell Membrane / metabolism
  • Filipin / pharmacology
  • Humans
  • Octoxynol / chemistry
  • Oligonucleotides
  • Receptors, Glucocorticoid / antagonists & inhibitors
  • Receptors, Glucocorticoid / metabolism*
  • Signal Transduction*
  • Transcription, Genetic*

Substances

  • CAV1 protein, human
  • Caveolin 1
  • Caveolins
  • Oligonucleotides
  • Receptors, Glucocorticoid
  • Filipin
  • Octoxynol