High-sensitive C-reactive protein, tumor necrosis factor alpha, and cardiovascular risk factors before and after weight loss in obese children

Metabolism. 2005 Sep;54(9):1155-61. doi: 10.1016/j.metabol.2005.03.022.


To confirm the existence of obesity-induced inflammation and to clarify the association between such inflammation and other cardiovascular risk factors, we investigated the relationships between high-sensitive C-reactive protein (hsCRP), tumor necrosis factor alpha (TNF-alpha), obesity, blood pressure, lipids, and insulin resistance in a long-term follow-up of obese children. We compared the serum concentrations of hsCRP, TNF-alpha, high-density lipoprotein cholesterol, and triglycerides as well as blood pressure and the insulin resistance index (homeostasis model assessment [HOMA]) of 14 nonobese and 31 obese children. Furthermore, we studied the changes in these parameters in 16 obese children who lost weight and in 15 obese children without weight change over a 1-year period. In the obese children, blood pressure (P=.003), HOMA (P=.034), and triglyceride (P=.011), TNF-alpha (P=.015), and hsCRP (P<.001) levels were significantly higher, whereas high-density lipoprotein cholesterol concentrations were significantly (P=.015) lower compared with the nonobese children. Weight loss was associated with a significant decrease in hsCRP (P=.008) and triglyceride (P=.048) levels, HOMA (P<.001), and blood pressure (P=.019), whereas there were no significant changes in the children with stable weight status. The changes in hsCRP and TNF-alpha levels over the 1-year period were not significantly correlated to the changes in lipids, blood pressure, and HOMA. Obese children demonstrated significantly higher levels of hsCRP and TNF-alpha compared with nonobese children. The chronic inflammation markers TNF-alpha and hsCRP were independent of lipids, blood pressure, and insulin resistance index. Weight loss was associated with the significant decrease of hsCRP and triglyceride levels, and blood pressure.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Biomarkers / blood
  • Blood Pressure
  • C-Reactive Protein / metabolism*
  • Child
  • Female
  • Follow-Up Studies
  • Humans
  • Insulin Resistance
  • Lipids / blood
  • Male
  • Obesity / blood
  • Obesity / epidemiology*
  • Obesity / immunology*
  • Risk Factors
  • Tumor Necrosis Factor-alpha / metabolism*
  • Weight Loss / immunology*


  • Biomarkers
  • Lipids
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein