Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients

Fabio Moreira; Mario Pedrazzoli; Fernando Morgadinho Dos Santos Coelho; Marcia Pradella-Hallinan; Maria Cecília Lopes da Conceição; Alberto Jorge Pereira Peregrino; Emílio Carlos de Oliveira; Sergio Tufik

doi:10.1016/j.molbrainres.2005.07.015

Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients

Brain Res Mol Brain Res. 2005 Oct 31;140(1-2):150-4. doi: 10.1016/j.molbrainres.2005.07.015. Epub 2005 Aug 25.

Authors

Fabio Moreira¹, Mario Pedrazzoli, Fernando Morgadinho Dos Santos Coelho, Marcia Pradella-Hallinan, Maria Cecília Lopes da Conceição, Alberto Jorge Pereira Peregrino, Emílio Carlos de Oliveira, Sergio Tufik

Affiliation

¹ Instituto do Sono/Depto. de Psicobiologia, Rua Napoleão de Barros, 925, 3- andar., São Paulo, SP, Brazil.

PMID: 16125818
DOI: 10.1016/j.molbrainres.2005.07.015

Abstract

Narcolepsy is a chronic sleep disorder. It is linked to the HLA-DQB1*0602 allele. A recent report established a genetic linkage between narcolepsy and the chromosomal region 4p13-q21 that contains the Clock gene. We studied two SNPs in the Clock gene aiming to find any association with narcolepsy. We did not find differences in genetic frequencies in the patients group. We concluded that these two SNPs are not associated with narcolepsy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
CLOCK Proteins
DNA Primers
HLA-DQ Antigens / genetics*
HLA-DQ beta-Chains
Humans
Membrane Glycoproteins / genetics*
Narcolepsy / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Single Nucleotide*
Trans-Activators / genetics*

Substances

DNA Primers
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DQB1 antigen
Membrane Glycoproteins
Trans-Activators
CLOCK Proteins
CLOCK protein, human