The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds

J Pediatr. 2005 Aug;147(2):263-6. doi: 10.1016/j.jpeds.2005.04.019.

Abstract

Hepatoblastoma is associated with familial adenomatous polyposis (FAP). In a series of 93 patients with hepatoblastoma,8 (8.6%) reported family histories suggestive of FAP. These and a review of reported FAP kindreds with hepatoblastoma may provide information helpful in counseling families with FAP.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenomatous Polyposis Coli / complications*
  • Adenomatous Polyposis Coli / genetics
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Genes, APC*
  • Hepatoblastoma / etiology*
  • Humans
  • Infant
  • Liver Neoplasms / etiology*
  • Male
  • Middle Aged
  • Mutation