The stages of type 1A diabetes

Ann N Y Acad Sci. 2005 Jun;1051:194-204. doi: 10.1196/annals.1361.061.


We can now predict the development of type 1 diabetes in man because it is a chronic autoimmune disorder with defined stages of disease. We can also readily prevent the disorder in animal models. A major goal is safe prevention in man, and for this we will almost certainly need a better understanding of pathogenesis, coupled with rigorous clinical trials.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmunity
  • Diabetes Mellitus, Type 1 / etiology*
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology
  • Environment
  • Genetic Predisposition to Disease
  • Humans
  • Insulin / metabolism
  • Insulin Secretion
  • Mice
  • Mice, Inbred NOD


  • Insulin