Perceived hunger is lower and weight loss is greater in overweight premenopausal women consuming a low-carbohydrate/high-protein vs high-carbohydrate/low-fat diet

J Am Diet Assoc. 2005 Sep;105(9):1433-7. doi: 10.1016/j.jada.2005.06.025.


The impact of a low-carbohydrate/high-protein diet compared with a high-carbohydrate/low-fat diet on ratings of hunger and cognitive eating restraint were examined. Overweight premenopausal women consumed a low-carbohydrate/high-protein (n=13) or high-carbohydrate/low-fat diet (n=15) for 6 weeks. Fasting body weight (BW) was measured and the Eating Inventory was completed at baseline, weeks 1 to 4, and week 6. All women experienced a reduction in BW (P<.01), although relative BW loss was greater in the low-carbohydrate/high-protein vs high-carbohydrate/low-fat group at week 6 (P<.05). Based on Eating Inventory scores, self-rated hunger decreased (P<.03) in women in the low-carbohydrate/high-protein but not in the high-carbohydrate/low-fat group from baseline to week 6. In both groups, self-rated cognitive eating restraint increased (P<.01) from baseline to week 1 and remained constant to week 6. Both diet groups reported increased cognitive eating restraint, facilitating short-term weight loss; however, the decrease in hunger perception in the low-carbohydrate/high-protein group may have contributed to a greater percentage of BW loss.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Body Mass Index
  • Diet, Reducing
  • Dietary Carbohydrates / administration & dosage*
  • Dietary Fats / administration & dosage*
  • Dietary Proteins / administration & dosage*
  • Energy Intake
  • Female
  • Humans
  • Hunger / physiology
  • Middle Aged
  • Obesity / diet therapy*
  • Premenopause
  • Satiety Response* / drug effects
  • Satiety Response* / physiology
  • Treatment Outcome
  • Weight Loss / physiology*


  • Dietary Carbohydrates
  • Dietary Fats
  • Dietary Proteins