Orbitofrontal cortex, associative learning, and expectancies

Neuron. 2005 Sep 1;47(5):633-6. doi: 10.1016/j.neuron.2005.07.018.


Orbitofrontal cortex is characterized by its unique pattern of connections with subcortical areas, such as basolateral amygdala. Here we distinguish between the critical role of these areas in associative learning and the pivotal contribution of OFC to the manipulation of this information to control behavior. This contribution reflects the ability of OFC to signal the desirability of expected outcomes, which requires the integration of associative information with information concerning internal states and goals in representational memory.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amygdala / physiology
  • Animals
  • Association Learning / physiology*
  • Behavior / physiology
  • Humans
  • Orbit / physiology*
  • Prefrontal Cortex / physiology*