Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice

Eur J Pharmacol. 2005 Sep 20;519(3):290-1. doi: 10.1016/j.ejphar.2005.07.022.


Adenosine A(2A) receptor knockout mice (A(2A)R KO) were compared to wild-type controls (A(2A)R WT) in a caffeine intake paradigm. When mice had ad libitum access to caffeine (0.3 g/l) and water in a two-bottle paradigm for 12 consecutive days, adenosine A(2A)R KO mice drank less caffeinated solution, demonstrating a reduced appetite for caffeine as compared to adenosine A(2A)R WT mice. These data reveal an important role for the adenosine A(2A) receptor in the appetitive properties of caffeine.

Publication types

  • Comparative Study

MeSH terms

  • Adenosine A2 Receptor Antagonists
  • Animals
  • Appetite / drug effects*
  • Appetite / physiology
  • Caffeine / administration & dosage*
  • Drinking / drug effects
  • Female
  • Genotype
  • Male
  • Mice
  • Mice, Knockout
  • Receptor, Adenosine A2A / genetics
  • Receptor, Adenosine A2A / physiology*


  • Adenosine A2 Receptor Antagonists
  • Receptor, Adenosine A2A
  • Caffeine