Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 13 (21), 5892-908

Plant-based Anticancer Molecules: A Chemical and Biological Profile of Some Important Leads

Affiliations
Review

Plant-based Anticancer Molecules: A Chemical and Biological Profile of Some Important Leads

Vandana Srivastava et al. Bioorg Med Chem.

Abstract

A number of natural products, with diverse chemical structures, have been isolated as anticancer agents. Several potential lead molecules such as camptothecin, vincristine, vinblastine, taxol, podophyllotoxin, combretastatins, etc. have been isolated from plants and many of them have been modified to yield better analogues for activity, toxicity or solubility. Several successful molecules like topotecan, irinotecan, taxotere, etoposide, teniposide, etc. also have emerged as drugs upon modification of these natural leads and many more are yet to come. In this review, the authors have focused on four important anticancer leads, that is, camptothecin, taxol, combretastatin A-4 and podophyllotoxin. Their chemistry, structure and activity relationships, biological activities, modes of action, analogue synthesis and future prospects have been discussed.

Similar articles

See all similar articles

Cited by 39 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback