Body Composition and Hormonal Adaptations Associated With Forskolin Consumption in Overweight and Obese Men

Obes Res. 2005 Aug;13(8):1335-43. doi: 10.1038/oby.2005.162.

Abstract

Objective: This study examined the effect of forskolin on body composition, testosterone, metabolic rate, and blood pressure in overweight and obese (BMI > or = 26 kg/m(2)) men.

Research methods and procedure: Thirty subjects (forskolin, n = 15; placebo, n = 15) were studied in a randomized, double-blind, placebo-controlled study for 12 weeks.

Results: Forskolin was shown to elicit favorable changes in body composition by significantly decreasing body fat percentage (BF%) and fat mass (FM) as determined by DXA compared with the placebo group (p < or = 0.05). Additionally, forskolin administration resulted in a change in bone mass for the 12-week trial compared with the placebo group (p < or = 0.05). There was a trend toward a significant increase for lean body mass in the forskolin group compared with the placebo group (p = 0.097). Serum free testosterone levels were significantly increased in the forskolin group compared with the placebo group (p < or = 0.05). The actual change in serum total testosterone concentration was not significantly different among groups, but it increased 16.77 +/- 33.77% in the forskolin group compared with a decrease of 1.08 +/- 18.35% in the placebo group.

Discussion: Oral ingestion of forskolin (250 mg of 10% forskolin extract twice a day) for a 12-week period was shown to favorably alter body composition while concurrently increasing bone mass and serum free testosterone levels in overweight and obese men. The results indicate that forskolin is a possible therapeutic agent for the management and treatment of obesity.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Basal Metabolism
  • Blood Pressure / drug effects
  • Body Composition* / drug effects
  • Bone Density / drug effects
  • Colforsin / administration & dosage
  • Colforsin / therapeutic use*
  • Double-Blind Method
  • Humans
  • Male
  • Obesity / blood
  • Obesity / drug therapy*
  • Obesity / pathology
  • Obesity / physiopathology
  • Overweight / drug effects*
  • Overweight / physiology
  • Testosterone / blood*

Substances

  • Colforsin
  • Testosterone