Diffuse idiopathic neuroendocrine cell hyperplasia causing severe airway obstruction in a patient with a carcinoid tumor

Respiration. 2006;73(5):690-3. doi: 10.1159/000088007. Epub 2005 Aug 30.


We report a 57-year-old female with severe airway obstruction who underwent resection of a tumor of unknown dignity during lung volume reduction surgery. The nodule consisted of a well-differentiated neuroendocrine tumor (carcinoid), and severe chronic obstructive lung disease was due to diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, a very rare cause of obliterative bronchiolitis. Radionuclide ablative therapy of the neuroendocrine tissue was considered but not found to be feasible due to a low lung/background ratio of the radiotracer.

Publication types

  • Case Reports

MeSH terms

  • Airway Obstruction / etiology*
  • Bronchiolitis Obliterans / etiology*
  • Carcinoid Tumor / complications
  • Carcinoid Tumor / pathology*
  • Female
  • Humans
  • Hyperplasia / etiology*
  • Lung Neoplasms / complications
  • Lung Neoplasms / pathology*
  • Middle Aged
  • Neuroendocrine Tumors / pathology*
  • Respiratory Mucosa / pathology